Download e-book for iPad: Acid-Base Regulation and Body Temperature by H. Rahn (auth.), Hermann Rahn Ph.D., Omar Prakash M.D.

By H. Rahn (auth.), Hermann Rahn Ph.D., Omar Prakash M.D. (eds.)

ISBN-10: 9400950047

ISBN-13: 9789400950047

ISBN-10: 9401087164

ISBN-13: 9789401087162

During the final twenty years teams of investigators have involved themselves with the matter of acid-base law at a number of physique temperatures. every one team, in expert isolation, pursued a separate direction. Surgeons and anesthe­ tists constructed innovations and instruments for hypothermic cardio-pulmonary by-pass operations and established their purpose for acid-base administration on in vitro versions of blood habit. Physiologists and biochemists, nevertheless, endeavored to appreciate acid-base legislation in dwelling organisms obviously subjected to alterations in physique temperature. simply within the final decade has there been an expanding understanding that every crew may benefit from the other's reports. With this objective in brain participants of either teams have been invited to provide their perspectives and observations within the wish of arriving at a greater knowing of acid-base administration in the course of hypothermia and gaining a better perception into the criteria which keep an eye on acid-base legislation in the course of normothermia. This ended in the presen­ tation of the current quantity with the purpose of delivering the clinician with a survey of current theories and the ensuing concepts for administration of the hypother­ mic sufferer. Acknowledgment The editors convey their nice appreciation to overlook Augusta Dustan for her devoted attempt within the instruction and modifying of the manuscripts. participants Heinz Becker, M. D. division of surgical procedure, collage of California scientific heart, Los An­ geles, l. a., CA 90024, U. S. A. Gerald D. Buckberg, M. D. division of surgical procedure, collage of California clinical heart, Los An­ geles, CA 90024, U. S. A.

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5). 0 10 o 6 10 20 30 37'C o Fig. 5. Arterial pH and PCO2 versus temperature relationships in the blood of a hibernator, the European hamster. Hand N: in vivo data recorded on the same animal, as he went from hibernation (H) to normothermy (N) (same data as Fig. 8). Solid lines represent the evolution of pH or PC02 in closed-system (anerobic) conditions in vitro, when temperature is either decreased from 37 to 6° C (N-N') starting from the normothermic condition, or increased from 6 to 37" C (H-H') starting from hibernation.

During deep hibernation, a low preoptic area of the hypothalamus (POAH) temperature is maintained in the face of ambient changes by appropriate thermogenic or thermolytic mechanisms; compared to normothermy, the set temperature and the gain of the regulation are much reduced, but the pattern is very similar. From the point of view of temperature regulation, hibernation thus resembles a negative fever, both hibernation and fever corresponding to a resetting of the hypothalamic thermostat. As we will see below, the same kind of resetting probably occurs for acid-base regulation.

Physiol Zool 56: 380--388, 1983. 22. Templeton lR: Reptiles. In: Comparative Physiology of Thermoregulation, Vol. 1. Whittow GC (ed). Academic Press, New York, 1970: 167-221. 23. Malan A: Respiration and acid-base state in hibernation. In: Hibernation and Torpor in Mammals and Birds, Lyman CP, Willis lS, Malan A, Wang LCH. Academic Press, New York, 1982: 237-282. 24. Grande F: Man under caloric deficiency. In: Handbook of Physiology. Sect. 4: Adaptation t ) the Environment, Dill DB (ed). : 911-937.

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Acid-Base Regulation and Body Temperature by H. Rahn (auth.), Hermann Rahn Ph.D., Omar Prakash M.D. (eds.)


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