By R. Guevara-Gonzalez
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Extra info for Aflatoxins - Biochemistry and Molecular Biology
It is in the interest of the cell to prevent activity of the foreign DNA because it could lead to undesirable mutations of genes (by transposon insertion) critical for function of the organism. , 2008). , 2010). Deletion mutants of these proteins have generally been associated with increased production of ST in A. nidulans except that deletion of laeA is associated with the loss of secondary metabolite production. In agreement with these gene disruption results, treatment of A. nidulans with the HDAC inhibitors, valproic acid or trichostatin A, increased metabolite production.
2002). Coordination of vesicle development was shown to be, in part, mediated by VeA and possibly by other proteins of the Velvet family. The organization and stability of such an organelle, obviously, is important for production of AF even if all of the biosynthetic genes are correctly transcribed, processed, and translated into proteins. The role of dedicated vesicles in the formation of AF could explain why in some cases, where the genes for AF biosynthesis are expressed and presumably the enzymes are made, no AF or precursor metabolites are formed.
Microbiol. 61, 23722377. K. (2003). The Aspergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR, Mol. Genet. Genomics 268, 711-719. , Bhatnagar, D. E. (2007). Genes differentially expressed by Aspergillus flavus strains after loss of aflatoxin production by serial transfers, Appl Microbiol Biotechnol 77, 917-925. R. R. (2009). The biology of chromatin remodeling complexes, Annu Rev Biochem 78, 273-304. J. & Melki, J. (2002). , Oncogene 21, 5380-5387. J.
Aflatoxins - Biochemistry and Molecular Biology by R. Guevara-Gonzalez