By Angélique Van’t Wout, Richard A. Koup, William A. Paxton (auth.), Hanneke Schuitemaker, Frank Miedema (eds.)
Infection with the human immunodeficiency virus is characterised via the destruction of the host immune approach as additionally mirrored by way of a revolutionary lack of CD4-positive T-cells. This ultimately leads to the host's incapability to house opportunistic infections and the immune surveillance of tumors, a medical prestige often called the got Immunodeficiency Syndrome (AIDS).
The ebook AIDS Pathogenesis offers the reader with an entire review of the scientific process HIV-1 an infection. It describes the medical features of basic an infection, different medical results of HIV-1 an infection, and techniques for anti-viral therapy. additionally, extra basic elements of HIV-1 an infection are reviewed. those contain the biology of the virus and the radical insights in AIDS pathogenesis. not just is the importance of an HIV-specific mobile and humoral immune reaction mentioned, but in addition the prospective inability of the grownup human host to house T-cell destruction. ultimately, the booklet discusses the at present used laboratory markers that permit for tracking of the scientific process infection.
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Extra resources for AIDS Pathogenesis
70 (1996), 3098-107. , Wolinsky, S. : Evidence for coinfection by multiple strains of human immunodeficiency virus type I infection subtype B in an acute seroconvertor, J Viral. 69 (I 995), 1324-1327. O. : Postnatal transmission of AIDSassociated retrovirus from mother to infant, Lancet i (1985), 896-898. CHAPTER3 BIOLOGICAL VARIABILITY OF HIV-1 JAN ALBERT 1 and MAARTEN KOOT2 Department of Clinical Virology, Swedish Institute for Infectious Disease Control, Karolinska Institute, S-I05 2I Stockholm, Sweden, and 2Department of Clinical Viro-Immunology of the CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University ofAmsterdam, Amsterdam, The Netherlands 1 1.
A rapid, simple assay can now determine the presence of plasma HIV resistant to most reverse transcriptase inhibitors . If antiretroviral therapy is to be used in those with primary HIV infection, it would be advantageous to determine the drug susceptibility prior to commencing therapy. Similar assays assessing protease inhibitor resistance are in development. 3. 1. T-cell Subsets Primary HIV infection is characterised by rapid changes in peripheral T-lymphocyte subsets [29,69,82,112]. During the first 1 to 2 weeks there characteristically is lymphopenia affecting both CD4+ and CD8+ subsets.
24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. Carr and Cooper Carr, A. : Primary HIV infection, in M. Sande and P. B. Saunders, pp. 89-106. , et al: Analysis ofT lymphocyte subsets in cytomegalovirus mononucleosis,.!. Immunol. 126 (1981), 2114-2116. Centers for Disease Control: CDC classification system for human T-lyrnphotropic virus type III/lymphadenopathy-associated virus infections, MMWR 3S (1986), 334-339. Centers for Disease Control: Case-control study of HIV seroconversion in health-care workers after percutaneous exposure to HIV-infected blood-France, United Kingdom, and United States, January 1988-August 1994, MMWR 44 (1995), 929-933.
AIDS Pathogenesis by Angélique Van’t Wout, Richard A. Koup, William A. Paxton (auth.), Hanneke Schuitemaker, Frank Miedema (eds.)